SecA inhibitors as potential antimicrobial agents: differential actions on SecA-only and SecA-SecYEG protein-conducting channels

Sec-dependent protein translocation is an essential process in bacteria. SecA is a key component of the translocation machinery and has multiple domains that interact with various ligands. SecA acts as an ATPase motor to drive the precursor protein/peptide through the SecYEG protein translocation ch...

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Detalhes bibliográficos
Publicado no:FEMS Microbiol Lett
Main Authors: Jin, Jinshan, Hsieh, Ying-Hsin, Chaudhary, Arpana S, Cui, Jianmei, Houghton, John E, Sui, Sen-fang, Wang, Binghe, Tai, Phang C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190897/
https://ncbi.nlm.nih.gov/pubmed/30007321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fny145
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