Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

Astroviruses are a global cause of pediatric diarrhea, but they are largely understudied, and it is unclear how and where they replicate in the gut. Using an in vivo model, here we report that murine astrovirus preferentially infects actively secreting small intestinal goblet cells, specialized epit...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cortez, Valerie, Boyd, David F., Crawford, Jeremy Chase, Sharp, Bridgett, Livingston, Brandi, Rowe, Hannah M., Davis, Amy, Alsallaq, Ramzi, Robinson, Camenzind G., Vogel, Peter, Rosch, Jason W., Margolis, Elisa, Thomas, Paul G., Schultz-Cherry, Stacey
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190700/
https://ncbi.nlm.nih.gov/pubmed/32350281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15999-y
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