Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

One of the major challenges limiting the efficacy of anti–PD-1/PD-L1 therapy in nonresponding patients is the failure of T cells to penetrate the tumor microenvironment. We showed that genetic or pharmacological inhibition of Vps34 kinase activity using SB02024 or SAR405 (Vps34i) decreased the tumor...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Noman, Muhammad Zaeem, Parpal, Santiago, Van Moer, Kris, Xiao, Malina, Yu, Yasmin, Viklund, Jenny, De Milito, Angelo, Hasmim, Meriem, Andersson, Martin, Amaravadi, Ravi K., Martinsson, Jessica, Berchem, Guy, Janji, Bassam
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190323/
https://ncbi.nlm.nih.gov/pubmed/32494661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax7881
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