PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis

Pulmonary fibrosis is characterized by pronounced collagen deposition and myofibroblast expansion, whose origin and plasticity remain elusive. We utilized a fate-mapping approach to investigate α-smooth muscle actin (αSMA)+ and platelet-derived growth factor receptor α (PDGFRα)+ cells in two lung fi...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Biasin, Valentina, Crnkovic, Slaven, Sahu-Osen, Anita, Birnhuber, Anna, El Agha, Elie, Sinn, Katharina, Klepetko, Walter, Olschewski, Andrea, Bellusci, Saverio, Marsh, Leigh M., Kwapiszewska, Grazyna
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189793/
https://ncbi.nlm.nih.gov/pubmed/32023084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00128.2019
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