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Fedratinib in myelofibrosis
Following the discovery of the JAK2V617F mutation in myeloproliferative neoplasms in 2005, fedratinib was developed as a small molecular inhibitor of JAK2. It was optimized to yield low-nanomolar activity against JAK2 (50% inhibitory concentration = 3 nM) and was identified to be selective for JAK2...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189288/ https://ncbi.nlm.nih.gov/pubmed/32343799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000954 |
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