Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma

Uterine leiomyosarcoma (ULMS) is the most lethal gynecologic malignancy with few therapeutic options. Chemoresistance prevails as a major hurdle in treating this malignancy, yet the mechanism of chemoresistance remains largely unclear. In this study, we certified MELK as a poor prognostic marker thr...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Zhang, Zhiwei, Sun, Chenggong, Li, Chengcheng, Jiao, Xinlin, Griffin, Brannan B., Dongol, Samina, Wu, Huan, Zhang, Chenyi, Cao, Wenyu, Dong, Ruifen, Yang, Xingsheng, Zhang, Qing, Kong, Beihua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188922/
https://ncbi.nlm.nih.gov/pubmed/32391256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00453
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