Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparabl...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wang, Liyuan, Liu, Dejun, Lv, Yuan, Cui, Lanqing, Li, Yun, Li, Tianmeng, Song, Huangwei, Hao, Yuxin, Shen, Jianzhong, Wang, Yang, Walsh, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187588/
https://ncbi.nlm.nih.gov/pubmed/31611352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01326-19
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