Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers

Tropifexor (LJN452) is a potent, orally available, non–bile acid farnesoid X receptor agonist under clinical development for chronic liver diseases. Here, we present results from a first‐in‐human study of tropifexor following single‐ and multiple‐ascending doses (SAD/MAD) and food effect substudy in...

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Vydáno v:Clin Pharmacol Drug Dev
Hlavní autoři: Badman, Michael K., Chen, Jin, Desai, Sachin, Vaidya, Soniya, Neelakantham, Srikanth, Zhang, Jie, Gan, Lu, Danis, Kate, Laffitte, Bryan, Klickstein, Lloyd B.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187203/
https://ncbi.nlm.nih.gov/pubmed/31823525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.762
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