Thioguanosine Conversion Enables mRNA‐Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC‐seq DUAL)

Temporal information about cellular RNA populations is essential to understand the functional roles of RNA. We have developed the hydrazine/NH(4)Cl/OsO(4)‐based conversion of 6‐thioguanosine (6sG) into A′, where A′ constitutes a 6‐hydrazino purine derivative. A′ retains the Watson–Crick base‐pair mo...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Autores principales: Gasser, Catherina, Delazer, Isabel, Neuner, Eva, Pascher, Katharina, Brillet, Karl, Klotz, Sarah, Trixl, Lukas, Himmelstoß, Maximilian, Ennifar, Eric, Rieder, Dietmar, Lusser, Alexandra, Micura, Ronald
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186826/
https://ncbi.nlm.nih.gov/pubmed/31999864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201916272
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