Thioguanosine Conversion Enables mRNA‐Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC‐seq DUAL)

Temporal information about cellular RNA populations is essential to understand the functional roles of RNA. We have developed the hydrazine/NH(4)Cl/OsO(4)‐based conversion of 6‐thioguanosine (6sG) into A′, where A′ constitutes a 6‐hydrazino purine derivative. A′ retains the Watson–Crick base‐pair mo...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Gasser, Catherina, Delazer, Isabel, Neuner, Eva, Pascher, Katharina, Brillet, Karl, Klotz, Sarah, Trixl, Lukas, Himmelstoß, Maximilian, Ennifar, Eric, Rieder, Dietmar, Lusser, Alexandra, Micura, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186826/
https://ncbi.nlm.nih.gov/pubmed/31999864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201916272
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