Tissue cross-reactivity studies of CPGJ701 in humans, cynomolgus monkeys and Sprague-Dawley rats and correlation analysis with in vivo toxicity

BACKGROUND: CPGJ701 is a recombinant humanized anti-human epidermal growth factor receptor-2 (HER2) monoclonal antibody-derivative of the cytotoxic agent maytansine (DM1) conjugate for the treatment of HER2-positive metastatic breast cancer. Tissue cross-reactivity (TCR) studies of CPGJ701 in a comp...

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Udgivet i:Ann Transl Med
Main Authors: Qu, Zhe, Lyu, Jianjun, Liu, Yue, Wang, Xin, Lin, Zhi, Yang, Yanwei, Zhang, Di, Geng, Xingchao, Li, Bo
Format: Artigo
Sprog:Inglês
Udgivet: AME Publishing Company 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186683/
https://ncbi.nlm.nih.gov/pubmed/32355769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2020.02.106
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