Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment

The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain neuronal polarity. The AIS actin cytoskeleton comprises actin patches and periodic sub-membranous actin rings. We demonstrate that tropomyosin is...

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Publicat a:iScience
Autors principals: Abouelezz, Amr, Stefen, Holly, Segerstråle, Mikael, Micinski, David, Minkeviciene, Rimante, Lahti, Lauri, Hardeman, Edna C., Gunning, Peter W., Hoogenraad, Casper C., Taira, Tomi, Fath, Thomas, Hotulainen, Pirta
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186529/
https://ncbi.nlm.nih.gov/pubmed/32344377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101053
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