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Glucocerebrosidase Defects as a Major Risk Factor for Parkinson’s Disease

Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), occur in a considerable percentage of all patients with sporadic Parkinson’s disease (PD), varying between 8% and 12% across the world. Genome wide association studies have confirmed the strong correla...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Aging Neurosci
Prif Awduron: Avenali, Micol, Blandini, Fabio, Cerri, Silvia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186450/
https://ncbi.nlm.nih.gov/pubmed/32372943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00097
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