Intrastriatal Administration of Exosome-Associated Pathological Alpha-Synuclein Is Not Sufficient by Itself to Cause Pathology Transmission

α-Synuclein (α-syn) has been genetically and biochemically linked to the pathogenesis of Parkinson’s disease (PD). There is accumulating evidence that misfolded α-syn species spread between cells in a prion-like manner and seed the aggregation of endogenous protein in the recipient cells. Exosomes h...

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Veröffentlicht in:Front Neurosci
Hauptverfasser: Karampetsou, Mantia, Sykioti, Vasia Samantha, Leandrou, Emmanouela, Melachroinou, Katerina, Lambiris, Alexandros, Giannelos, Antonis, Emmanouilidou, Evangelia, Vekrellis, Kostas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186405/
https://ncbi.nlm.nih.gov/pubmed/32372894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00246
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