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Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
The cyclic GMP-AMP synthase (cGAS) is a widely used DNA sensor, which detects cytosolic DNA species without a preference of self or non-self microbial DNA in interphase to initiate innate immune response. How cGAS is regulated to avoid self-DNA sensing upon nuclear envelope breakdown (NEBD) during m...
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| 發表在: | Cell Discov |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer Singapore
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7186227/ https://ncbi.nlm.nih.gov/pubmed/32351706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0162-2 |
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