ER stress increases store-operated Ca(2+) entry (SOCE) and augments basal insulin secretion in pancreatic beta cells

Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although many studies have attempted to...

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Опубликовано в: :J Biol Chem
Главные авторы: Zhang, Irina X., Ren, Jianhua, Vadrevu, Suryakiran, Raghavan, Malini, Satin, Leslie S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Membrane Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186166/
https://ncbi.nlm.nih.gov/pubmed/32179650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012721
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