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ER stress increases store-operated Ca(2+) entry (SOCE) and augments basal insulin secretion in pancreatic beta cells
Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although many studies have attempted to...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7186166/ https://ncbi.nlm.nih.gov/pubmed/32179650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012721 |
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