Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood. RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of the top genes induced by PM in macrophages. Acod1 encodes a mit...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Sun, Kaitlyn A, Li, Yan, Meliton, Angelo Y, Woods, Parker S, Kimmig, Lucas M, Cetin-Atalay, Rengül, Hamanaka, Robert B, Mutlu, Gökhan M
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185992/
https://ncbi.nlm.nih.gov/pubmed/32255424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54877
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