A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

BACKGROUND: Intravascular-thrombosis and extravascular-lipid-deposition are the two key pathogenic events considered to interrupt intraosseous blood supply during steroid-associated osteonecrosis (ON) development. However, there are no reported candidate agents capable of simultaneously targeting th...

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Detalles Bibliográficos
Publicado en:Bone
Main Authors: Zhang, Ge, Qin, Ling, Sheng, Hui, Wang, Xin-Luan, Wang, Yi-Xiang, Yeung, David Ka-Wai, Griffith, James F., Yao, Xin-Sheng, Xie, Xin-Hui, Li, Zi-Rong, Lee, Kwong-Man, Leung, Kwok-Sui
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185883/
https://ncbi.nlm.nih.gov/pubmed/19015051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2008.10.035
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