Antibody–Drug Conjugates Using Mouse–Canine Chimeric Anti-Dog Podoplanin Antibody Exerts Antitumor Activity in a Mouse Xenograft Model

Antibody–drug conjugates (ADCs), which consist of a monoclonal antibody (mAb), a linker, and a payload, can deliver a drug to cancer tissues. We previously produced an anti-dog podoplanin (dPDPN) mAb, PMab-38, which reacts with dPDPN-expressing canine melanomas and squamous cell carcinomas (SCCs), b...

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Detalhes bibliográficos
Publicado no:Monoclon Antib Immunodiagn Immunother
Main Authors: Kato, Yukinari, Ito, Yuji, Ohishi, Tomokazu, Kawada, Manabu, Nakamura, Takuro, Sayama, Yusuke, Sano, Masato, Asano, Teizo, Yanaka, Miyuki, Okamoto, Saki, Handa, Saori, Komatsu, Yu, Takei, Junko, Kaneko, Mika K.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185362/
https://ncbi.nlm.nih.gov/pubmed/32182186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mab.2020.0001
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