Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease

The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding is a mechanism of glomerular endothelial glycocalyx damage in vitro, resulting in increased albumin permeability. Here we sought to deter...

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Publicado en:Kidney Int
Main Authors: Ramnath, Raina D., Butler, Matthew J., Newman, Georgina, Desideri, Sara, Russell, Amy, Lay, Abigail C., Neal, Chris R., Qiu, Yan, Fawaz, Sarah, Onions, Karen L., Gamez, Monica, Crompton, Michael, Michie, Chris, Finch, Natalie, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184681/
https://ncbi.nlm.nih.gov/pubmed/32037077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.09.035
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