Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes

BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase sensitivity to DNA-damaging agents. There are conflicting data regarding the prognostic value of BRCA germline mutations in breast cancer (BC) patients. We collected clinical, pathological and genetic data of a cohort 9...

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Pubblicato in:Sci Rep
Autori principali: Talhouet, Solene De, Peron, Julien, Vuilleumier, Aurelie, Friedlaender, Alex, Viassolo, Valeria, Ayme, Aurélie, Bodmer, Alexandre, Treilleux, Isabelle, Lang, Noemie, Tille, Jean- Christophe, Chappuis, Pierre O., Buisson, Adrien, Giraud, Sophie, Lasset, Christine, Bonadona, Valerie, Trédan, Olivier, Labidi-Galy, S.Intidhar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184602/
https://ncbi.nlm.nih.gov/pubmed/32341426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63759-1
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