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p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis
The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7184554/ https://ncbi.nlm.nih.gov/pubmed/31973890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.12.014 |
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