Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

Signaling pathways that sense amino acid abundance are integral to tissue homeostasis and cellular defense. Our laboratory has previously shown that halofuginone (HF) inhibits the prolyl-tRNA synthetase catalytic activity of glutamyl-prolyl-tRNA synthetase (EPRS), thereby activating the amino acid r...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Kim, Yeonjin, Sundrud, Mark S., Zhou, Changqian, Edenius, Maja, Zocco, Davide, Powers, Kristen, Zhang, Miao, Mazitschek, Ralph, Rao, Anjana, Yeo, Chang-Yeol, Noss, Erika H., Brenner, Michael B., Whitman, Malcolm, Keller, Tracy L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183223/
https://ncbi.nlm.nih.gov/pubmed/32253314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913788117
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