Computational design of probes to detect bacterial genomes by multivalent binding

Rapid methods for diagnosis of bacterial infections are urgently needed to reduce inappropriate use of antibiotics, which contributes to antimicrobial resistance. In many rapid diagnostic methods, DNA oligonucleotide probes, attached to a surface, bind to specific nucleotide sequences in the DNA of...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Curk, Tine, Brackley, Chris A., Farrell, James D., Xing, Zhongyang, Joshi, Darshana, Direito, Susana, Bren, Urban, Angioletti-Uberti, Stefano, Dobnikar, Jure, Eiser, Erika, Frenkel, Daan, Allen, Rosalind J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183166/
https://ncbi.nlm.nih.gov/pubmed/32241887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918274117
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