Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease

The interplay of transcription factors and cis-regulatory elements (CREs) orchestrates the dynamic and diverse genetic programs that assemble the human central nervous system (CNS) during development and maintain its function throughout life. Genetic variation within CREs plays a central role in phe...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Cherry, Timothy J., Yang, Marty G., Harmin, David A., Tao, Peter, Timms, Andrew E., Bauwens, Miriam, Allikmets, Rando, Jones, Evan M., Chen, Rui, De Baere, Elfride, Greenberg, Michael E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183164/
https://ncbi.nlm.nih.gov/pubmed/32265282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922501117
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