Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation element-binding (CPEB) protein, is a putative substrate of long-lasting memories. We isolated aggregated Drosophila CPEB, Orb2, from adult heads...

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Udgivet i:Science
Main Authors: Hervas, Ruben, Rau, Michael J., Park, Younshim, Zhang, Wenjuan, Murzin, Alexey G., Fitzpatrick, James A.J., Scheres, Sjors H.W., Si, Kausik
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182444/
https://ncbi.nlm.nih.gov/pubmed/32165583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba3526
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