Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Endogenous costimulatory molecules on T cells such as 4-1BB (CD137) can be leveraged for cancer immunotherapy. Systemic administration of agonistic anti–4-1BB antibodies, although effective preclinically, has not advanced to phase 3 trials because they have been hampered by both dependency on Fcγ re...

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Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Claus, Christina, Ferrara, Claudia, Xu, Wei, Sam, Johannes, Lang, Sabine, Uhlenbrock, Franziska, Albrecht, Rosmarie, Herter, Sylvia, Schlenker, Ramona, Hüsser, Tamara, Diggelmann, Sarah, Challier, John, Mössner, Ekkehard, Hosse, Ralf J., Hofer, Thomas, Brünker, Peter, Joseph, Catherine, Benz, Jörg, Ringler, Philippe, Stahlberg, Henning, Lauer, Matthias, Perro, Mario, Chen, Stanford, Küttel, Christine, Bhavani Mohan, Preethi L., Nicolini, Valeria, Birk, Martina Carola, Ongaro, Amandine, Prince, Christophe, Gianotti, Reto, Dugan, Gregory, Whitlow, Christopher T., Sai, Kiran Kumar Solingapuram, Caudell, David L., Burgos-Rodriguez, Armando G., Cline, J. Mark, Hettich, Michael, Ceppi, Maurizio, Giusti, Anna Maria, Crameri, Flavio, Driessen, Wouter, Morcos, Peter N., Freimoser-Grundschober, Anne, Levitsky, Victor, Amann, Maria, Grau-Richards, Sandra, von Hirschheydt, Thomas, Tournaviti, Stella, Mølhøj, Michael, Fauti, Tanja, Heinzelmann-Schwarz, Viola, Teichgräber, Volker, Colombetti, Sara, Bacac, Marina, Zippelius, Alfred, Klein, Christian, Umaña, Pablo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181714/
https://ncbi.nlm.nih.gov/pubmed/31189721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav5989
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