A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models

One of the pathways of the unfolded protein response, initiated by PKR-like endoplasmic reticulum kinase (PERK), is key to neuronal homeostasis in neurodegenerative diseases. PERK pathway activation is usually accomplished by inhibiting eIF2α-P dephosphorylation, after its phosphorylation by PERK. L...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ganz, Javier, Shacham, Talya, Kramer, Maria, Shenkman, Marina, Eiger, Hagit, Weinberg, Nitai, Iancovici, Ori, Roy, Somnath, Simhaev, Luba, Da’adoosh, Benny, Engel, Hamutal, Perets, Nisim, Barhum, Yael, Portnoy, Moshe, Offen, Daniel, Lederkremer, Gerardo Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181660/
https://ncbi.nlm.nih.gov/pubmed/32327686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63899-4
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