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Direct-acting antiviral treatment downregulates immune checkpoint inhibitor expression in patients with chronic hepatitis C
Chronic hepatitis C (CHC) infection is associated with increased TIM-3, PD-1 immune checkpoint receptors expression that inhibits adaptive T cells and increases NK cell cytotoxicity against T helper cells, both resulting T cell exhaustion. Elimination of the virus with direct-acting antivirals (DAAs...
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| Publicado no: | Clin Exp Med |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7181552/ https://ncbi.nlm.nih.gov/pubmed/32108916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10238-020-00618-3 |
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