Burosumab versus continuation of conventional therapy in children with X-linked hypophosphatemia: a randomised, active-controlled, open-label, phase 3 trial

BACKGROUND: X-linked hypophosphatemia in children is characterized by elevated serum FGF23, hypophosphatemia, rickets, lower extremity bowing, and growth impairment. We compared the efficacy and safety of continuing conventional therapy, consisting of oral phosphate and active vitamin D, versus swit...

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Bibliografske podrobnosti
izdano v:Lancet
Main Authors: Imel, Erik A., Glorieux, Francis H., Whyte, Michael P., Munns, Craig F., Ward, Leanne, Nilsson, Ola, Simmons, Jill H., Padidela, Raja, Namba, Noriyuki, Cheong, Hae Il, Pitukcheewanont, Pisit, Sochett, Etienne, Högler, Wolfgang, Muroya, Koji, Tanaka, Hiroyuki, Gottesman, Gary S., Biggin, Andrew, Perwad, Farzana, Mao, Meng, Chen, Chao-Yin, Skrinar, Alison, Martin, Javier San, Portale, Anthony A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179969/
https://ncbi.nlm.nih.gov/pubmed/31104833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(19)30654-3
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