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Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility
Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix s...
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| Udgivet i: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7179633/ https://ncbi.nlm.nih.gov/pubmed/32179530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00261-20 |
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