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ISEcp1-Mediated Transposition Leads to Fosfomycin and Broad-Spectrum Cephalosporin Resistance in Klebsiella pneumoniae

A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella pneumoniae isolate was recovered, and whole-genome sequencing revealed ISEcp1-bla(CTX-M-14b) tandemly inserted upstream of the chromosomally encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and fosA gene...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kieffer, Nicolas, Poirel, Laurent, Mueller, Linda, Mancini, Stefano, Nordmann, Patrice
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179579/
https://ncbi.nlm.nih.gov/pubmed/32122889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00150-20
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