Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs)

Zinc (II) ions (hereafter simplified as zinc) are important for the structural and functional activity of many proteins. For Cu, Zn superoxide dismutase (Sod1), zinc stabilizes the native structure of each Sod1 monomer, promotes homo-dimerization and plays an important role in activity by “softening...

Full description

Saved in:
Bibliographic Details
Published in:Molecules
Main Authors: Boyd, Stefanie D., Ullrich, Morgan S., Calvo, Jenifer S., Behnia, Fatemeh, Meloni, Gabriele, Winkler, Duane D.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179120/
https://ncbi.nlm.nih.gov/pubmed/32121118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25051086
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items