Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice

To determine whether Cav1.2 voltage-gated Ca(2+) channels contribute to astrocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 α subunit was deleted in GFAP-positive astrocytes. This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of myeli...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Zamora, Norma N., Cheli, Veronica T., Santiago González, Diara A., Wan, Rensheng, Paez, Pablo M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2020
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178909/
https://ncbi.nlm.nih.gov/pubmed/32169969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1644-19.2020
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