Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investig...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Shimojo, Masafumi, Takuwa, Hiroyuki, Takado, Yuhei, Tokunaga, Masaki, Tsukamoto, Satoshi, Minatohara, Keiichiro, Ono, Maiko, Seki, Chie, Maeda, Jun, Urushihata, Takuya, Minamihisamatsu, Takeharu, Aoki, Ichio, Kawamura, Kazunori, Zhang, Ming-Rong, Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178904/
https://ncbi.nlm.nih.gov/pubmed/32265258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2880-19.2020
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