Stabilized diverse HIV-1 envelope trimers for vaccine design

One of the major goals in HIV-1 vaccine development is to achieve properly folded and stabilized envelope glycoprotein (Env) trimers that mimic the native Env on the mature virion. Here, we design and characterize uncleaved prefusion-optimized (UFO) trimers for 12 Envs currently circulating in China...

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Publicado en:Emerg Microbes Infect
Autores principales: Wang, Qian, Ma, Bingting, Liang, Qingtai, Zhu, Angqi, Wang, Hua, Fu, Lili, Han, Xiaoxu, Shi, Xuanling, Xiang, Ye, Shang, Hong, Zhang, Linqi
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178897/
https://ncbi.nlm.nih.gov/pubmed/32241249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2020.1745093
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