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Emerging New Concepts of Degrader Technologies
Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and accessible binding sites whose occupancy influences the function of the target protein. These requirements preclude many disease-causing proteins from...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Ltd.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7177145/ https://ncbi.nlm.nih.gov/pubmed/32416934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2020.04.005 |
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