Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case–control pharmacokinetic study

Cytochrome P450s (CYP450) family is one of the most critical factors in the metabolism process. Hence, the present study aims to characterize the activity of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5, and P-glycoprotein (P-gp) pump in patients with type 2 diabetes (T2DM). This characterizati...

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Published in:MethodsX
Main Authors: Neyshaburinezhad, Navid, Rouini, Mohammadreza, Shirzad, Nooshin, Esteghamati, Alireza, Nakhjavani, Manouchehr, Namazi, Soha, Ardakani, Yalda H.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Pharmacology, Toxicology and Pharmaceutical Science
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176986/
https://ncbi.nlm.nih.gov/pubmed/32337164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mex.2020.100853
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