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Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment

The stereoselective synthesis of the (Z)-enamide fragment of chondrochloren (1) is described. A Buchwald-type coupling between amide 3 and (Z)-bromide 4 was used to generate the required fragment. The employed amide 3 comprising three chiral centers was obtained through a seven-step sequence startin...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Beilstein J Org Chem
Prif Awduron: Geldsetzer, Jan, Kalesse, Markus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Beilstein-Institut 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176928/
https://ncbi.nlm.nih.gov/pubmed/32362944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.16.64
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