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FOXO1 deficiency impairs proteostasis in aged T cells
T cell differentiation involves the dynamic regulation of FOXO1 expression, which rapidly declines after activation and is subsequently restored. Reexpression is impaired in naïve CD4(+) T cell responses from older individuals. Here, we show that FOXO1 promotes lysosome function through the inductio...
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| Yayımlandı: | Sci Adv |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Association for the Advancement of Science
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7176426/ https://ncbi.nlm.nih.gov/pubmed/32494657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba1808 |
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