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Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures

Many potential chemotherapeutics fail to reach patients. One of the key reasons is that compounds are tested during the drug discovery stage in two-dimensional (2D) cell cultures, which are often unable to accurately model in vivo outcomes. Three-dimensional (3D) in vitro tumor models are more predi...

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Dettagli Bibliografici
Pubblicato in:Anal Chem
Autori principali: Tobias, Fernando, McIntosh, Julie C., LaBonia, Gabriel J., Boyce, Matthew W., Lockett, Matthew R., Hummon, Amanda B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176368/
https://ncbi.nlm.nih.gov/pubmed/31755703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b03536
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