Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

It is well known that various developmental signals play diverse roles in hematopoietic stem and progenitor cell (HSPC) production; however, how these signaling pathways are orchestrated remains incompletely understood. Here, we report that Rab5c is essential for HSPC specification by endocytic traf...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Heng, Jian, Lv, Peng, Zhang, Yifan, Cheng, Xinjie, Wang, Lu, Ma, Dongyuan, Liu, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176290/
https://ncbi.nlm.nih.gov/pubmed/32275659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000696
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