Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: A randomized, controlled trial

BACKGROUND: An elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long perio...

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Détails bibliographiques
Publié dans:PLoS Med
Auteurs principaux: Tanaka, Atsushi, Taguchi, Isao, Teragawa, Hiroki, Ishizaka, Nobukazu, Kanzaki, Yumiko, Tomiyama, Hirofumi, Sata, Masataka, Sezai, Akira, Eguchi, Kazuo, Kato, Toru, Toyoda, Shigeru, Ishibashi, Ryoichi, Kario, Kazuomi, Ishizu, Tomoko, Ueda, Shinichiro, Maemura, Koji, Higashi, Yukihito, Yamada, Hirotsugu, Ohishi, Mitsuru, Yokote, Kotaro, Murohara, Toyoaki, Oyama, Jun-ichi, Node, Koichi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176100/
https://ncbi.nlm.nih.gov/pubmed/32320401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003095
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