Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

The GPR17 receptor, expressed on oligodendroglial precursors (OPCs, the myelin producing cells), has emerged as an attractive target for a pro-myelinating strategy in multiple sclerosis (MS). However, the proof-of-concept that selective GPR17 ligands actually exert protective activity in vivo is sti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Parravicini, Chiara, Lecca, Davide, Marangon, Davide, Coppolino, Giusy Tindara, Daniele, Simona, Bonfanti, Elisabetta, Fumagalli, Marta, Raveglia, Luca, Martini, Claudia, Gianazza, Elisabetta, Trincavelli, Maria Letizia, Abbracchio, Maria P., Eberini, Ivano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176092/
https://ncbi.nlm.nih.gov/pubmed/32320409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231483
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados