Evidence that Brain-Reactive Autoantibodies Contribute to Chronic Neuronal Internalization of Exogenous Amyloid-β(1-42) and Key Cell Surface Proteins During Alzheimer’s Disease Pathogenesis

Blood-brain barrier (BBB) permeability is a recognized early feature of Alzheimer’s disease (AD). In the present study, we examined consequences of increased BBB permeability on the development of AD-related pathology by tracking selected leaked plasma components and their interactions with neurons...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Goldwaser, Eric L., Acharya, Nimish K., Wu, Hao, Godsey, George A., Sarkar, Abhirup, DeMarshall, Cassandra A., Kosciuk, Mary C., Nagele, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175946/
https://ncbi.nlm.nih.gov/pubmed/32039847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190962
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