SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

Melatonin exerts direct neuroprotection against cerebral hypoxic damage, but the mechanisms of its action on microglia have been less characterized. Using both in vitro and in vivo models of hypoxia, we here focused on the role played by silent mating type information regulation 2 homolog 1 (SIRT1)...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Merlo, Sara, Luaces, Juan Pablo, Spampinato, Simona Federica, Toro-Urrego, Nicolas, Caruso, Grazia Ilaria, D’Amico, Fabio, Capani, Francisco, Sortino, Maria Angela
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175216/
https://ncbi.nlm.nih.gov/pubmed/32120833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10030364
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