Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

BACKGROUND: Activated protein C (APC), a serine protease with antithrombotic effects, protects in animal models of ischemic stroke by suppressing inflammation and enhancing vascular integrity, angiogenesis, neurogenesis and neuroprotection. A small number of animal studies suggest it might also have...

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Détails bibliographiques
Publié dans:Front Neurosci
Auteurs principaux: Kant, Ravi, Halder, Sebok K., Fernández, Jose A., Griffin, John H., Milner, Richard
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174764/
https://ncbi.nlm.nih.gov/pubmed/32351356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00333
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