Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D

The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (F(passive)) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. PKD phosphorylates myofilam...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Herwig, Melissa, Kolijn, Detmar, Lódi, Mária, Hölper, Soraya, Kovács, Árpád, Papp, Zoltán, Jaquet, Kornelia, Haldenwang, Peter, Dos Remedios, Cris, Reusch, Peter H., Mügge, Andreas, Krüger, Marcus, Fielitz, Jens, Linke, Wolfgang A., Hamdani, Nazha
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174613/
https://ncbi.nlm.nih.gov/pubmed/32351396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00240
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