Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma

Patients diagnosed with T-cell leukemias and T-cell lymphomas (TCLs) still have a poor prognosis and an inadequate response to current therapies, highlighting the need for targeted treatments. We have analyzed the potential therapeutic value of the farnesyltransferase inhibitor, tipifarnib, in 25 TC...

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Pubblicato in:Sci Rep
Autori principali: Alonso-Alonso, Ruth, Mondéjar, Rufino, Martínez, Nerea, García-Diaz, Nuria, Pérez, Cristina, Merino, David, Rodríguez, Marta, Esteve-Codina, Anna, Fuste, Berta, Gut, Marta, Burrows, Francis, Scholz, Catherine, Vaqué, Jose Pedro, Gualberto, Antonio, Piris, Miguel Ángel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174413/
https://ncbi.nlm.nih.gov/pubmed/32317694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63434-5
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