Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the negative ATP binding inter-ring cooperativity of GroEL-GroES. Here we report the crystal structure of an ATP (ADP:BeF(3)-bound) ground-state mimic double-ring mHsp60(14)-(mHsp10(7))(2) football complex, and the cryo-EM st...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gomez-Llorente, Yacob, Jebara, Fady, Patra, Malay, Malik, Radhika, Nisemblat, Shahar, Chomsky-Hecht, Orna, Parnas, Avital, Azem, Abdussalam, Hirsch, Joel A., Ubarretxena-Belandia, Iban
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174398/
https://ncbi.nlm.nih.gov/pubmed/32317635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15698-8
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