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Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the negative ATP binding inter-ring cooperativity of GroEL-GroES. Here we report the crystal structure of an ATP (ADP:BeF(3)-bound) ground-state mimic double-ring mHsp60(14)-(mHsp10(7))(2) football complex, and the cryo-EM st...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7174398/ https://ncbi.nlm.nih.gov/pubmed/32317635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15698-8 |
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