Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer

BACKGROUND: Clinical trials have shown the ability of therapeutic vaccines to generate immune responses to tumor-associated antigens (TAAs). What is relatively less known is if this translates into immune-cell (IC) infiltration into the tumor microenvironment. This study examined whether neoadjuvant...

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Опубликовано в: :J Immunother Cancer
Главные авторы: Abdul Sater, Houssein, Marté, Jennifer L, Donahue, Renee N, Walter-Rodriguez, Beatriz, Heery, Christopher R, Steinberg, Seth M, Cordes, Lisa M, Chun, Guinevere, Karzai, Fatima, Bilusic, Marijo, Harmon, Stephanie A, Turkbey, Ismail Baris, Choyke, Peter L, Schlom, Jeffrey, Dahut, William L, Madan, Ravi A, Pinto, Peter A, Gulley, James L
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2020
Предметы:
Clinical/Translational Cancer Immunotherapy
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174144/
https://ncbi.nlm.nih.gov/pubmed/32269146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000655
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