Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer

BACKGROUND: Clinical trials have shown the ability of therapeutic vaccines to generate immune responses to tumor-associated antigens (TAAs). What is relatively less known is if this translates into immune-cell (IC) infiltration into the tumor microenvironment. This study examined whether neoadjuvant...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Abdul Sater, Houssein, Marté, Jennifer L, Donahue, Renee N, Walter-Rodriguez, Beatriz, Heery, Christopher R, Steinberg, Seth M, Cordes, Lisa M, Chun, Guinevere, Karzai, Fatima, Bilusic, Marijo, Harmon, Stephanie A, Turkbey, Ismail Baris, Choyke, Peter L, Schlom, Jeffrey, Dahut, William L, Madan, Ravi A, Pinto, Peter A, Gulley, James L
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2020
Sujets:
Clinical/Translational Cancer Immunotherapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174144/
https://ncbi.nlm.nih.gov/pubmed/32269146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000655
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